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Ah, sounds like it might be worth it (if you are really anal and/or bored) to set up a "Summer" and "Winter" distributor to deal with climate and gas formulation changes.
In practice, you just retard the initial timing setting a little or richen the carb adjustment, but it becomes a perpetual process of adjusting and readjusting to get the best performance from each tank of gas in any weather or altitude. Computers are great for this kind of stuff, but how many people are still using computers that where designed/built in 1979. Think Atari 
One day, I'll learn more about that megasquirt system and update my wifes daily driver to a modern fuel injection style system. Till then, I just let it warm up in the driveway for a moment each morning and try not to focus on gas mileage too much.
